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Endocrinology, 142(12), 5182-5189

When overactive, it lowers NAD+ levels and promotes fat accumulation , particularly in visceral (deep belly) fat

A user who starts at 35% body fat will likely see more benefit from a 16-week cycle than a user starting at 20% body fat

The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications