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To compare young versus naturally aged phenotypes, an independent cohort of C57BL/6 J mice was maintained from 10 weeks to 27 months of age under identical husbandry conditions

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The underlying pathogenesis of AF was not fully established, but the evidence regarding AF and oxidative stress was accumulated 2

Yamasaki C., Tashiro S., Nishito Y., Sueda T., Igarashi K., J

Additionally, the GSH depletion impairs GPX4 activity, as GSH is a necessary cofactor, leading to unchecked lipid peroxidation

In this reaction first and second carbons of Xylulose-5-Phosphate