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While effective for approximately 50% of men , they tend to work best in mild to moderate cases of ED

Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

Its structure resists degradation, supporting longer laboratory procedures

Mild discomfort

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Common side effects are temporary and can include redness, dryness, stinging or burning, slight swelling and reactivation of cold sores