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The OHP-induced cytotoxicity in primary Schwann cells and the myelin basic protein expression decreasing indicated that the platinum derivatives also induced Schwann cells mitochondrial dysfunction in vitro [90]

W.BrunnerM.Erdjument-BromageH.GeromanosS.TempstP.et al (1993)

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On the other hand, the toxicity of quinoa saponins was demonstrated by the upregulation of phenoloxidase, catalase, and glutathione S-transferase activities, which confirmed the capacity of saponins to induce damage to insect cuticles by penetrating insects and reacting as oxidative stressors

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