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There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49

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Both compounds significantly reduced body-weight gain in obese mice, an effect associated with increased in vivo fat oxidation and elevated plasma glycerol a direct index of lipolysis

Tesamorelin (a GHRH analog) targets visceral fat through the GH/IGF-1 axis