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Heptanoate can be metabolized to propionyl-CoA, producing succinyl-CoA after carboxylation and thereby re-filling a key substrate of the tricarboxylic acid (TCA) cycle [167]

Another example is the use of in situ oxygen generation, such as by Coronel et al., where, by using calcium peroxide encapsulated in polydimethylsiloxane tablets, oxygen was raised from 0.1 mmHg to 214 mmHg, resulting in reduced anaerobic glycolysis and stimulating insulin release in pancreatic islets

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