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In addition, ACC1 (cytosolic) is highly expressed in lipogenic tissues, such as liver and adipose tissue, while ACC2 (mitochondrial membrane) is majorly expressed in oxidative tissues, such as cardiac and skeletal muscle, which are consistent with the functions of ACC1 in lipogenesis and ACC2 in regulating fatty acid -oxidation (23)

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Due to these promising results in preclinical evaluations, resveratrol has been subjected to a phase I clinical trial against colon cancer and at the used dose, showed potential in chemoprevention [316]

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