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Targeting metabotropic glutamate receptors in the treatment of epilepsy: Rationale and current status

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In a murine model, it was demonstrated that the treatment with high-dose of PPAR agonists worsened the tubular damage

strains, including two enzyme activities: L-carnitine dehydratase (CDH, EC 4.2.1.89) and crotonobetaine reductase (CR, EC 1.3.99) [15, 16] (Fig 1A)