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The effects of two different doses of PXN (PXN LOW, PXN HIGH), CAF (CAF HIGH), and a control group on cognition (escape latency in the Morris water maze test), neurotransmitters (acetylcholine, dopamine, and gamma-aminobutyric acid), and neurochemicals (BDNF, catalase, glutathione, and cyclic GMP) were analyzed from whole brain samples in young (8 weeks old) and aged (16 months old) rats

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Furthermore, we validated on drug penetration into cells, putting forward that the internalization of our nano-machinery may be mediated by TLR2

The spectral changes at both excitation wavelengths followed identical kinetics, which allowed us to reliably monitor the formation of roGFP2 WT (S 2 ), roGFP2 C151S (SSG), or roGFP2 C208S (SSG) using PfGrx C32S/C88S (SSG) as an oxidant (Fig