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CR induces specific mechanisms involved in pathogenic or adaptative EMT-driven stem cell response and proliferation of mucosa epithelial cells

T-box transcription factors are well-known for their function in several cellular processes such as organogenesis, cell cycle, self-renewal, and differentiation of embryonic and several other adult stem cells [41, 42]

10.1002/alz.13016

In summary, SFN appears to impact not only core behavioral symptoms but also the gut microbiome, which might facilitate overall neurological health and gastrointestinal comfort

Hyperglycemia drives the accumulation of advanced glycation end products AGEs, which activate the RAGE/MAPK signaling axis, thereby inhibiting Col-II synthesis and promoting a catabolic state in chondrocytes (31)