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The results of study suggest that oxidative stress, proinflammatory effects, and apoptosis are all factors that contribute to 5FUinduced nephrotoxicity

First, it acts as a vehicle of copper, an element essential for multiple enzymes responsible for connective tissue formation, antioxidant activity, and cellular respiration

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A study of independently living people between 65 and 90 years of age found that almost 25% consumed less than the recommended riboflavin intake, and 10% had biochemical evidence of deficiency (117)

doi: 10.3389/fphar.2019.01605 137 TongJZhangYYuPLiuJMeiXMengJ