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This epigenetic reprogramming extends to DNA, where 2HG heightening is strongly linked to the glioma CpG island methylator phenotype (G-CIMP) observed in grade II/III gliomas and glioblastomas

Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy

Curcumin regulates the expression of keap1 and restores the function of NRF2, promoting insulin sensitivity and redox homeostasis [158,160,161]

conversely, an Nrf2 inhibitor abolishes its anti-inflammatory and antiferroptotic effects (164)

developed a vaccine platform consisting of autologous DCs pulsed with tumor membrane vesicles (TMVs) encapsulating personalized tumor antigens, which showed anti-tumor effects in HER2-positive breast cancer and triple-negative breast cancer (Munoz et al., 2021)
