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J Phys Chem B 113(25):86078612

Chen, TianfengJournal of Materials Chemistry B: Materials for Biology and Medicine (2018), 6 (4), 568-579CODEN: JMCBDV

Mitochondria cannot manufacture glutathione de novo , so glutathione is synthesized in the cytosol and a small fraction of the total cellular pool is then imported into the mitochondrial matrix by carrier-mediated transport (22

In mouse models, the team introduced combined therapy including PD-L1 blocker and cyst(e) inase (a bioengineered enzyme that degrades cystine and cysteine) and such treatment can enhance the efficacy of CTL-mediated anticancer effects, supporting the idea that inducing ferroptosis could be considered a productive way for treating cancer and overcoming immunotherapy resistance (Wang et al., 2019)

They are not designed for direct tissue repair in the way BPC-157 is