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Author contributions Authors responsible for concept and design were M.J.H., H.Y.H., Y.L

Consistently, they reduce DHA into ascorbate with a better efficiency ( k cat around 10 4 s 1 , k cat / K m around 10 7 M 1 .s 1 ) compared to the other enzymes ( k cat around 10 2 s 1 ) and to the reduction of glutathionylated-mercaptoethanol, the product formed upon incubation between GSH and HED ( k cat around 10 2 s 1 ) (Table 5) (Dixon et al., 2003)

PS-MPs exposure to human occur directly through the drinking water, inhalation, skin and ingestion