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Given the extensive role of HIF-1 in GBM progression, metabolic adaptation, and therapy resistance, it remains a critical target for novel therapeutic interventions aimed at disrupting tumor survival mechanisms in hypoxic microenvironments

The GSH/GSSG ratio was lower in diamide-treated hearts, and 4-ClDzp blunted the increase in GSSG seen with diamide alone

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Declining levels directly impair oxidative phosphorylation and ATP production (Stein & Imai, 2012)

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However, the NF-B signaling is uncontrolled when the R702W gene is mutated, protecting the organism against the harm caused by oxidative stress induced by H