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10.1152/ajpendo.00073.2017 56 LiG.LuanG.HeY.TieF.WangZ.SuoY.et al (2018a)

While its suppression alleviates chronic inflammation, complete inhibition of NF-B signaling has been shown to impair osteoblast proliferation, migration, and early differentiation, suggesting that its therapeutic targeting must be finely tuned in terms of dosage, timing, and pathway specificity
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