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2.2 Animals and ethical statement The present study was conducted on male Wistar rats at Shahid Beheshti University in Tehran, Iran

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766 However, long-term treatment at high doses can lead to mutations in the BD and overexpression of ATP-binding cassette subfamily B member 1 (ABCB1), which contributes to drug resistance development

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The translocation of -catenin to the nucleus occurs following activation by the Wnt ligand, thereby facilitating transcription of downstream gene transcription factors that play a pivotal role in shaping the morphology, growth, and regeneration of intestinal epithelial cells (Jung and Park, 2020)

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