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The following diagram easily explains this phenomenon

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The red arrows in Figure 1 show what we call long-range interactions, in which substrates allosterically affect distant enzymes in the network

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Benefits to human have also been shown [7]

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Ca(2+) homeostasis and endoplasmic reticulum (ER) stress: an integrated view of calcium signaling

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10.1007/bf02917486 Summary Keywords disulfiram, diethyldithiocarbamate, copper, disulfiram copper complex, drug repurposing, drug-delivery-system, cancer, cancer stem cells Citation Kannappan V, Ali M, Small B, Rajendran G, Elzhenni S, Taj H, Wang W and Dou QP (2021) Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents

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[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Anderson EJ, Neufer PD

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