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Previous studies have elucidated that the TGF-/SMAD pathway mediates apoptosis of vascular endothelial cells ( TGF- may also induce CNI-related ED via non-SMAD signaling pathways, such as the RhoA/ROCK, RAS/MEK/ERK, and PI3K pathways ( via catalyzing the deacetylation of acetyl-L-lysine side chains in histones ( via cooperating with TGF- after CNI, which also supports the above hypothesis

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Hashimoto, M., Im, S

Botanical polysaccharides: macrophage immunomodulation and therapeutic potential

discovered that combining 2,6-DHAP with diammonium hydrogen citrate (DAHC) can prevent the fragmentation of fragile peptides, disulfide bonds, and small proteins during MALDI-MS analysis