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This OS imbalance can harm sperm cells by causing mitochondrial damage and altering essential cellular components, including lipids, nucleic acids, and proteins [39]

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In some embodiments, the moles of total siRNA molecules relative to moles of total lipids are about 1: 5, about 1: 6, about 1: 7, about 1: 8, about 1: 9, about 1: 10, about 1: 11, about 1: 12, about 1: 13, about 1: 14, about 1: 15, about 1: 16, about 1: 17, about 1: 18, about 1: 19, or about 1: 20

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