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doi: 10.2337/dc13-0143 101 den HeijerTVermeerSEvan DijkEJPrinsNDKoudstaalPJHofmanAet al

In a type 1 diabetic Akita mouse model, which was used as a nonobese insulin-dependent model of spontaneous type 1 diabetes, empagliflozin treatment attenuated diabetes-induced rise in renal expression of markers of kidney growth by reducing the cyclin-dependent kinase inhibitors p27 and p21, which were over-expressed in early diabetic kidneys (152)

In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)

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Dairy products: Milk, yoghurt and cheese are rich in b12 Some cereals and nutritional yeast are fortified with vitamin b12 which makes them an alternative for those who dont consume enough animal-based products