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The significance of this pathway extends beyond simple vasodilation

However, where more than one therapeutic approach was applied, such as an adjunctive immune modulator, intravesical injection, intravesical instillation with BTX or HA, or HA and CS, or changes in diet, more positive outcomes could be anticipated which could be demonstrated in the future by RCTs

By inhibiting PDK, DCA facilitates PDH-mediated conversion of pyruvate to acetyl-CoA, thus enhancing mitochondrial oxidative capacity and reducing lactate buildup [142]

D., & Tapiero, H

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It can also exhibit medical benefits in patients with diabetes and hypertension