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Available online at: www.fda.gov/regulatory-information/search-fda-guidance-documents/testicular-toxicity-evaluation-during-drug-development (Accessed December 19, 2024)

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A typical protocol looks like this: Initial loading (for severe deficiency or pernicious anemia): Daily or every-other-day injections for 1 to 2 weeks, then weekly for 4 weeks Maintenance (pernicious anemia, ongoing absorption issues): Monthly injections indefinitely General wellness or dietary deficiency: Once every 1 to 3 months, depending on levels Your provider will check your B12 blood levels and recommend the right schedule for you