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Pathway dysregulation has been observed in the brain, urine and plasma of PD patients, showing a significant reduction of antioxidant enzyme activity along with an increased level of oxidative stress (Kovac et al., 2015), the loss of dopaminergic neurons in association with microglia activation (Rojo et al., 2010) and exacerbation of synuclein aggregation (Lastres-Becker et al., 2012)

IgG complex formation and C4d concentrations were determined using the MicroVue CIC EIA and MicroVue C4d EIA kits (Quidel) following the manufacturer instructions

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International Agency for Reserach on Cancer (IARC), 165-169, 2015

30 (2), e14576

Clinical Features CVS occurs in all age groups, although it is more common in children