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doi: 10.3390/jcm11206102 145 PatelVPauliNBiggsEBarbourLBoruffB

The addition of DMSO-loaded (3%) polymerosomes to the cells (serum-free culture medium) caused an increase in the levels of sulfane sulfur-containing compounds (Table 1), and this increase might be a reason for the increase in the cells demand for the enzymes involved in the formation of sulfur-donor molecules (mainly CTH) and their distribution (mainly MPST, TST)hence the observed change associated with an increase in CTH expression (Figure 4C) and CTH, MPST, and TST activity (Figure 5C)

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It exerts a protective effect by scavenging peroxynitrite and preventing the release of AIF and EndoG from mitochondria and subsequent nuclear DNA breakage (Du et al., 2015)