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The accumulation of misfolded protein in the endoplasmic reticulum (ER) leads to ER dysfunction, which is known as ER stress ( 12 regulated ER homeostasis ( 12 deficiency activated ER stress pathways by increasing the phosphorylation of PERK and IRE1 and the expression of ATF6 ( 12 could promote nerve regeneration after TBI by regulating ER stress

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doi: 10.1007/s12094-010-0514-8

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