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Additionally, immune cells such as macrophages and neutrophils produce free radicals to combat pathogens in a process known as the respiratory burst [23]

The resulting acute pulmonary edema severely impairs gas exchange, leading to profound hypoxemia, respiratory distress, and rapid death due to cardiogenic shock

Sarocchi, M

Despite extensive research, no definite biomarker for diagnosis or treatment has been detected (6)

Genomic characterization revealed PM(2.5)-Associated mutational signatures in lung cancer including activation of APOBEC3B

However, the same environment carries the risk of oxidative damage, such as 8-oxo-7,8-dihydroguanine (8-oxoG) and single- or double-strand breaks, which activate base excision and other DNA repair pathways