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How do the four amino acid substitutions in CJC-1295 differ from native GHRH(1-29)

Integr Biol 2:326337 Le Joncour V, Laakkonen P (2018) Seek & Destroy, use of targeting peptides for cancer detection and drug delivery

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This finding contrasts with observations in transformed cells where Arg deprivation more robustly induces ribosome pausing and GCN2 activation compared with Leu starvation (Darnell et al, 2018)

This selectivity reduces confounding variables in experimental designs focused on the somatotropic axis