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9 Immunosenescence is also regulated by signaling pathways such as the nuclear factor-kappa B (NF-B), mTOR, JAK-STAT, melatonin, and sirtuin pathways, whose dysregulation leads to aberrant immune responses and increased susceptibility to age-related diseases

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Therefore, it should be administered multiple times to prevent plasma level fluctuations [12, 13]

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Data availability The data that support the findings of this study are available in source data files linked to each figure

A selection of DAMP classifications, their corresponding receptors, and associated diseases are summarized in Table 1