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Another possible regulatory pathway of P450 by cannabinoids involves indirect influence on the noradrenergic and serotonergic transmission in specific brain regions, such as the locus coeruleus (major noradrenergic brainstem nucleus) and the dorsal raphe nuclei (the largest serotonergic nucleus) (Michelsen et al., 2008
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On day 78, rats were allowed to concurrent three-bottle choice access of 10% and 20% (vol/vol) ethanol solutions and water for 24 additional days
Cancer Res 50 , 60756086 (1990)
However, it is still advised to consult your doctor for personalized guidance
