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Role of Reductive versus Oxidative Stress in Tumor Progression and Anticancer Drug Resistance

Introduction Glutathione is a tripeptide found in many tissues at relatively high concentrations, namely 110 mM in cells, similarly to glucose, potassium, and cholesterol, with a critical role in several physiological processes, such as redox balance preservation, reduction of oxidative stress through detoxification from xenobiotic and endogenous compounds, and immune system modulation ( Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases ( Although the pathogenic role of oxidative stress in NAFLD pathogenesis is well established ( 2

Acknowledgments This work was supported by NIH grants CA180126 and AG017242 and a grant from KRIBB Research Initiative Program (awarded to Yousin Suh)

Mediterranean diet and telomere length: a systematic review and meta-analysis

Bobkova et al

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance