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Doses start very low (0.25 mg weekly for semaglutide) and titrate up slowly

Unlike oral supplements that may take weeks to absorb and are often less effective due to digestive limitations injectable B12 works quickly and efficiently

The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases

It's sterile water that contains 0.9% benzyl alcohol, which acts as a preservative

Vitamin B6 deficiency can occur in individuals with poor-quality diets that are deficient in many nutrients
