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Studies have found that inhibiting KGDD activity due to mutations in IDH1/2, FH, or SDH increases sensitivity to DNA damaging agents, and the mechanisms described are due to changes in methylation (Inoue et al., 2016

doi: 10.26442/00403660.2022.04.201480

This correlates well with the fact that TyrOH is regulated by the binding of catecholamines, while PheOH is regulated by the substrate binding to an allosteric site (Fitzpatrick, 2015)

doi: 10.1507/endocrj.EJ16-0359 136 CossonEBenbaraAPharisienINguyenMTRevauxALormeauBet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Sadeghi O., Nasiri M., Maghsoudi Z., Pahlavani N., Rezaie M., Askari G