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Recent studies have found Hepatic stellate cells (HSCs) can induce overexpression of miRNA-1246 in HCC, which can activate this pathway by suppressing the expression of its target gene, ROR, and in this way promote EMT (144)

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Interestingly, and in line with previous reports of our group, we observed elevated secretion of the produced m + 3 serine in HIF KO NSCLC models compared to HIF WT cells (Figure S2A, C), providing a means to modulate the tumor microenvironment [10, 39]

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