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Bi-Est (a combination of estriol and estradiol, typically in an 80:20 ratio) remains the most commonly prescribed compounded estrogen preparation

This significantly increases its bioavailability.

In other words, the mis-compartmentalization of zinc in AD interferes with signaling by the NMDA receptor, which can lead to intracellular excitatory toxicity [196] (Figure 7)

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Higgins et al., 2024) (Supplementary Table S1)

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