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[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Rikani A.A., Choudhry Z., Choudhry A.M., Rizvi N., Ikram H., Mobassarah N.J., Tulli S

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Drug Metabolism and Disposition, 45(12), 1266-1275

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In addition, mature myeloid immune cells display altered phenotypes and functions with elevated production of proinflammatory cytokines such as TNF- and IL-6, which are closely related to age-related senescent inflammation, termed senoinflammation

In inflamed joints, infiltrating immune cells and synovial resident cells have great requirements for energy and nutrients, and they adapt their metabolic profiles to generate sufficient energy to support their highly activated inflammatory states