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Antioxidant Microbial Metabolites The microbiome plays a pivotal role in systemic redox balance by generating a variety of antioxidant metabolites, such as fatty acids, secondary bile acids, sphingolipids, polyamines, tryptophan, and indole derivatives

Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38

They're all downstream of the same underlying cellular environment

Step 3: Production of Eumelani, the dark, brown pigment associated with hyperpigmentation and tanning [4]

Excess fat and ROS damage cells, causing inflammation 69, 70

Supports normal collagen production with vitamin C