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The dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer

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In mammals, there are five known isoforms of HKs including HK1, HK2, HK3, HK4, and the hexokinase domain-containing protein-1 (HKDC1) 36

The activation of macrophages is also followed by translocation of mitogen-activated protein kinases (MAPKs) to the nucleus where they phosphorylate the transcription factor NF-kappa B, thus activating a pro-inflammatory immune response