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Epigenetically, mitochondrial sirtuin 3 deficiency leads to hyperacetylation of TCA enzymes, increasing lactate and nicotinamide adenine dinucleotide production and contributing to sepsis-induced myocardial dysfunction (66)

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To distinguish the roles of GHS-R in neurons from peripheral tissues, we generated a conditional knockout mouse line using neuron-specific driver of Synapsin-cre

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