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less commonly used in adults Partial enteral nutrition may supplement medical therapy and support nutritional status Total parenteral nutrition (TPN) indicated for severe malnutrition, short bowel syndrome post-resection, or surgical preparation 17

This article reviews the significant roles of gut microbial metabolites, such as short-chain fatty acids, tryptophan, and bile acids, in ferroptosis in IBD

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Chronically supraphysiological IGF-1 carries risks

2 Translational potential of neurotrophic factors MS, especially in the progressive disease phase, poses therapeutic challenge as current disease modifying therapies fail to address the complex crosstalk between glial cells, neurons and CNS-infiltrating cells as well as their highly dynamic functions ( Highlighting the functional dynamics of astrocytes, depletion of reactive astrocytes in early neuroinflammation increased disease severity in EAE, while depletion of reactive astrocytes during the chronic disease phase ameliorated disease pathogenesis (129, 130)