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Some very preliminary research has suggested a theoretical concern about long-term supplementation lowering the bodys natural production, but this is not well-established

[DOI] [PMC free article] [PubMed] [Google Scholar] Hopperton KE, Mohammad D, Trpanier MO, Giuliano V, Bazinet RP

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HDACs have also been linked to hyperglycemia by promoting gluconeogenesis in the liver

Unlike growth hormone releasing peptides that must be taken away from food, GHK-Cu can be administered regardless of meal timing