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Thus, while IN chelation is promising for directly targeting the brain and CNS, it still requires careful consideration of formulation strategies (e.g., nanoparticle targeting or controlled-release systems) to improve site specificity, especially for drugs with a narrow therapeutic window

GH leaves the systemic circulation and crosses the blood-brain barrier (BBB) reaching its responsive sites in the brain, including the choroid plexus, hypothalamus, and hippocampus

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Moreover, lysophosphatidylcholine accumulation in the lung may increase the permeability of alveolar epithelium, disrupt lung surfactant, and stimulate pro-inflammatory lung microenvironment 42

Neurotransmitters like norepinephrine bind to astrocyte receptors, activating the cAMP pathway to promote glycogen synthesis

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