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Glutathione is a potent antioxidant found in every cell of the human body, composed of three amino acids: cysteine, glutamine, and glycine

To explore how these mutations impact systemic metabolism, we investigated serum metabolomic profiles of male (N=6) and female (N=11) PD patients carrying LRRK2 mutations, compared with age- and sex-matched HCs (male, N=23

The naturally occurring peptide GHK-Cu (GHK from glycyl-L-histidyl-L-lysine bound to a copper ion), which affects 31.2% of the human genes by either activating or deactivating them (based on a criterion of a reduction or increment in gene activity of more than 50%), meaning that it works by inducing epigenetic alterations in the cells

Therefore, these observations suggest that downregulating the expression and activity of the aforementioned proteins associated with melanosome transport may be useful for reversing the process of skin hyperpigmentation

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