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Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis

Drug synergism was measured using the Loewe model with Combenefit software (Cancer Research UK Cambridge Institute), and the combination index was calculated using CompuSyn software (ComboSyn) ( 3 Results 3.1 CB-839 treatment inhibits glutathione synthesis and the conversion of glutamine to glutamate in CLL cell lines Initially, we investigated CB-839s functional inhibition of GLS-1 ( Figures 1A, B )

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West J Surg Obstet Gynecol

The aggregates were incubated for an additional 24 hours