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Raijmakers MT, Steegers EA, Peters WH

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

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(2017) provided the first data on in vivo mast cell-microglial interactions, demonstrating that activation of brain mast cells by injecting the mast cell degranulator, C48/80 directly into the hypothalamus triggered microglial activation and the release of the pro-inflammatory cytokines, IL-6 and TNF-

Moreover, HoxB8 knock out mice, a gene expressed by a subpopulation of microglia, has been associated with increased grooming behaviors similar in nature to TS, OCD and ASD (Chen et al., 2010) and as seen in the Hdc KO model of TS