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Thus, unlike single-treatment, which may only very partially depict possible NO-system involvement, BPC 157, known to induce NO-release by itself [98,99], is always investigated under the condition of the triple regimen, and may equally overwhelm the adverse effects of L-NAME, L-arginine, and their combination as well [97]

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The Role of Oxidative Stress and Inflammation While the conversation around melasma often focuses on pigment, the root causes are often deeper