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Until the 1980s, when its antioxidant action was discovered, bilirubin was thought to be a harmful by-product linked with the potentially fatal disorders of neonatal hyperbilirubinemias, acute hepatitis, and cirrhosis

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Phase III exports conjugates for elimination

Copper acts as a cofactor in various enzymes and performs essential roles in photosynthesis, respiration and the electron transport chain, and is a structural component of defense genes

Acta Haematol 1971

By inhibiting TGF- pathways and reducing collagen deposition, they protect podocytes and endothelial cells from injury, slowing CKD progression