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A total of 172 patients were included in these 28 studies, with ages ranging from 1 day to 7 years

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Among patients with established ASCVD, it is well known that adverse cardiovascular events can be reduced when risk factors such as hypertension, dyslipidemia, smoking, inactivity, and obesity are well controlled.1 In addition to controlling the magnitude of an individual risk factor, several studies have suggested that increased intra-individual variability in biological measures, such as blood pressure, is associated with all-cause mortality, cardiovascular death, or stroke.2, 3, 4 Although LDL-C reduction with statin therapy is the main treatment for established ASCVD, few studies have evaluated the association between variability in LDL-C levels and cardiovascular outcomes

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