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This can be achieved by contact-dependent signaling [juxtracrine signaling], by the release of exosomes in close proximity to the source [paracrine signaling], or by endocrine signaling whereby exosomes are then transported systemically via the bloodstream to act distally

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Junctate A Ca 2+ -binding, integral endoplasmic reticulum (ER) membrane protein that induces and/or stabilizes peripheral coupling between the ER and the plasma membrane