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For FRAA-positive participants, improvement in verbal communication was significantly greater in those receiving folinic acid as compared with those receiving placebo, resulting in an effect of 7.3 (1.4,13.2) standardized points with a large effect size (Cohens d =0.91), indicating that folinic acid treatment may be more efficacious in children with ASD who are FRAA positive

For example, the homozygous GSTM1 deletion genotype imposes a near 2-fold increased risk for autism

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Free Radic Biol Med 1992, 12:337345